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Association details:
| Biomarker: | EGFR L861Q |
|---|---|
| Cancer: | Esophageal Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Afatinib against Esophageal or Head-and-Neck Squamous Cell Carcinoma: Significance of Activating Oncogenic HER4 Mutations in HNSCC
Excerpt:
These results suggest that apoptosis is induced in response to afatinib in the KYSE270 cell line carrying the activating EGFR L861Q mutation via the inhibition of the EGFR signal.
DOI:
10.1158/1535-7163.MCT-15-0737
