EGFR exon 19 deletions (Ex19del) or exon 21 substitution mutation (Ex21.L858R) received RAM (10 mg/kg Q2W) plus GEF (250 mg/day) until disease progression or unacceptable toxicity….The objective response rate was 70.7% (95% CI: 59.6–80.3), disease control rate was 98.8% (95% CI: 93.4–100.0), and duration of response was immature at this point in time with a censoring rate of 56.9% where the median point estimate was 13.6 months (95% CI: 11.1–18.2).

Eligible for first-line treatment with erlotinib based on documented evidence of tumor harboring an activating EGFR mutation [exon 19 deletion or exon 21 (L858R) substitution mutation].

The 1-year PFS rate with RAM plus GEF was 62.9% (95% CI: 50.3–73.1); 2-year PFS rate was 26.1% (95% CI: 16.2–37.0) (Table 2). Median PFS was 14.1 months (95% CI: 12.3–17.9) (Fig. 3). Subgroup analyses for EGFR mutation type were performed; 1-year PFS rate (95% CI) was 67.2% (48.6–80.3) and 59.2% (41.4–73.3) for ex19del and ex21.L858R subgroups, respectively....RELAY+ revealed a favorable benefit–risk profile for RAM plus GEF in the first-line treatment of East Asian patients with EGFR-mutated NSCLC.