...Signed and dated informed consent 18-75years,ECOG PS:0-2,Life expectancy of more than 3 months,with measurable lesion ( RECIST1.1) Histologically or cytologically confirmed, locally advanced and/or metastatic IIIB, IIIC or IV non-squamous NSCLC or recurrent non-squamous NSCLC(according to the 8th Edition of the AJCC Staging system)with EGFR 19 del or 21 L858R gene mutation and concomitant others....