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Association details:
| Biomarker: | EGFR exon 21 mutation |
|---|---|
| Cancer: | Small Cell Lung Cancer |
| Drug: | gefitinib (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors
Published date:
05/19/2021
Excerpt:
In vitro experiments were conducted to study the role of ETS variant transcription factor 1 (ETV1) on SCLC transformation and TKIs resistance….Another patient harbored an EGFR exon 21 mutation (p.L858R) with a long-lasting response to first-line gefitinib and then transformed to SCLC.
DOI:
10.1200/JCO.2021.39.15_suppl.e20568
