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    Association details:
    Biomarker:EGFR exon 20 insertion
    Cancer:Lung Non-Squamous Non-Small Cell Cancer
    Drug:Rybrevant (amivantamab-vmjw) (EGFR inhibitor, c-MET inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    Source:
    NCCN
    Published date:
    12/21/2023
    Excerpt:
    Non-Small Cell Lung Cancer: EGFR Exon 20 Insertion Mutation…Subsequent therapy...Amivantamab-vmjw + carboplatin + pemetrexed (nonsquamous)...
    Secondary therapy:
    carboplatin + pemetrexed
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrials.gov
    Title:

    A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

    Excerpt:
    ...- Participant must have histologically or cytologically confirmed, locally advanced or metastatic, nonsquamous non-small cell lung cancer (NSCLC) with documented primary epidermal growth factor receptor (EGFR) Exon 20ins activating mutation...
    Trial ID:
    PAPILLON