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Association details:
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Phase III Study of Nazartinib (EGF816) Versus Erlotinib/Gefitinib in First-line Locally Advanced / Metastatic NSCLC With EGFR Activating Mutations

Excerpt:
...- Histologically documented locally advanced or metastatic, stage IIIB/ IIIC or stage IV NSCLC with documented EGFR activating mutation (L858R or ex19del)...
Trial ID:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

Study of EGF816 in Combination With Selected Targeted Agents in EGFR-mutant NSCLC

Excerpt:
...- Patients must have histologically or cytologically confirmed locally advanced (stage IIIB) or metastatic (stage IV) EGFR mutant (ex19del, L858R) NSCLC....
Less C2 evidence
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Nazartinib (EGF816) in patients with treatment-naïve EGFR-mutant non-small cell lung cancer (NSCLC): Updated phase II results.

Published date:
05/13/2020
Excerpt:
Tx-naïve adult pts with activating EGFR-mut (L858R or ex19del), stage IIIB/IV adv NSCLC with neurologically stable and controlled brain metastasis (BM) received oral nazartinib 150 mg once daily...ORR by BIRC: 69%; median PFS by BIRC: 18 mo; median OS was NE and at 33 mo,56% of pts were alive...Nazartinib is a promising 3rd generation EGFR TKI for tx-naïve pts with adv EGFR-mut NSCLC, including pts with baseline BM.
DOI:
10.1200/JCO.2020.38.15_suppl.9574
Trial ID:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Phase II results for single-agent nazartinib (EGF816) in adult patients (pts) with treatment-naive EGFR-mutant non-small cell lung cancer (NSCLC)

Published date:
10/01/2018
Excerpt:
 Treatment-naive pts with NSCLC harboring activating EGFR mutations (L858R and/or ex19del) received oral nazartinib 150 mg QD on a continuous schedule….Nazartinib demonstrated a tolerable safety profile and promising efficacy, with durable responses in treatment-naive pts with advanced EGFR-mutant NSCLC, including pts with baseline BM.
DOI:
10.1093/annonc/mdy424.073
Trial ID: