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Association details:
| Biomarker: | EGFR exon 19 deletion + EGFR T790M |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report
Published date:
08/07/2020
Excerpt:
We report a case of a 64-year-old Asian man with epidermal growth factor receptor T790M-positive adenocarcinoma....they harbored an exon 19 deletion mutation in EGFR...The patient was initially treated with afatinib, which resulted in a partial response…
DOI:
10.1186/s13256-020-02447-0
