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    Association details:
    Biomarker:EGFR exon 19 deletion + EGFR T790M
    Cancer:Lung Adenocarcinoma
    Drug:Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    New
    Source:
    J Med Case Rep
    Title:

    An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report

    Published date:
    08/07/2020
    Excerpt:
    We report a case of a 64-year-old Asian man with epidermal growth factor receptor T790M-positive adenocarcinoma....they harbored an exon 19 deletion mutation in EGFR...The patient was initially treated with afatinib, which resulted in a partial response…
    DOI:
    10.1186/s13256-020-02447-0