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Association details:
| Biomarker: | EGFR exon 19 deletion + EGFR K754E |
|---|---|
| Cancer: | Lung Adenocarcinoma |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Efficacy of afatinib for pulmonary adenocarcinoma with leptomeningeal metastases harboring an epidermal growth factor receptor complex mutation (exon 19del+K754E): A case report
Published date:
10/23/2020
Excerpt:
A 42-year-old woman with lung adenocarcinoma and leptomeningeal metastasis was admitted...Next-generation sequencing of CSF and peripheral blood samples identified an EGFR complex mutation (exon19del+K754E)….the patient started oral afatinib...continued to respond to afatinib treatment (30 mg once daily) with minimal adverse effects.
DOI:
10.1097/MD.0000000000022851
