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    Association details:
    Biomarker:EGFR D770_N771insSVD
    Cancer:Lung Adenocarcinoma
    Drug:Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    Source:
    Gan To Kagaku Ryoho
    Title:

    A Case of Advanced Lung Adenocarcinoma Harboring an Epidermal Growth Factor Receptor(EGFR) Exon 20 Insertion, D770_N771insSVD

    Published date:
    06/01/2021
    Excerpt:
    A 57-year-old female was diagnosed as having advanced lung adenocarcinoma...harbored an epidermal growth factor receptor(EGFR)exon 20 insertion, D770_N771insSVD. Afatinib, a second-generation EGFR-tyrosine kinase inhibitor (TKI), was administered as the fourth-line treatment and reduced the size in several lesions.