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Association details:
| Biomarker: | EGFR C797S |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations
Published date:
05/15/2020
Excerpt:
Therapeutic testing in mice revealed that both erlotinib and afatinib caused regression of osimertinib-resistant C797S-containing tumors, whereas only afatinib was effective on L718Q mutant tumors.
DOI:
10.1158/0008-5472.CAN-19-3819
