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Association details:
| Biomarker: | EGFR amplification |
|---|---|
| Cancer: | Lung Cancer |
| Drug: | Conmana (icotinib) (EGFR inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib
Published date:
11/20/2020
Excerpt:
This cohort study included 371 lung cancer patients....we found that the proportion of EGFR amplification in patients with drug resistance was higher than that in patients with drug sensitivity (40% vs 0%)....EGFR amplification was commonly detected in patients with acquired lcotinib/gefitinib resistance.
DOI:
10.1038/s41598-020-76791-y
