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Association details:
| Biomarker: | EGFR amplification |
|---|---|
| Cancer: | Glioblastoma |
| Drug: | Visudyne (verteporfin) (Reactive oxygen species stimulant, Photosensitizer) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma
Published date:
11/10/2020
Excerpt:
...the benzoporphyrin derivative verteporfin, a disruptor of YAP/TAZ-TEAD mediated transcription, preferentially induced apoptosis of cultured patient-derived EGFR-amplified/mutant GBM cells, suppressed expression of YAP/TAZ transcriptional targets, including EGFR, and conferred significant survival benefit in an orthotopic xenograft GBM model....Together, our data suggest that verteporfin is a promising therapeutic agent for EGFR amplified and mutant GBM.
DOI:
10.1158/1078-0432.CCR-20-0018
