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Association details:
| Biomarker: | EGFR amplification + ERBB2 amplification |
|---|---|
| Cancer: | Gastroesophageal Cancer |
| Drug: | Gilotrif (afatinib) (EGFR inhibitor, HER2 inhibitor, HER4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Excerpt:
Afatinib response was associated with coamplification of EGFR and ERBB2….Analysis of patients with ERBB2-amplified, trastuzumab-resistant EG cancer who were treated with the HER kinase inhibitor afatinib revealed that sensitivity and resistance to therapy were associated with EGFR/ERBB2 coamplification and MET amplification, respectively.
DOI:
10.1158/2159-8290
