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DRUG CLASS:

E-selectin inhibitor

DRUG CLASS:

E-selectin inhibitor

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FLT3-ITD mutation + WT1 mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation + WT1 mutation	Acute Myelogenous Leukemia	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D
WT1 mutation	Acute Myelogenous Leukemia	WT1 mutation	Acute Myelogenous Leukemia	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D	sorafenib + GMI-1359 Sensitive: D – Preclinical sorafenib + GMI-1359 Sensitive : D
FLT3-ITD mutation	Acute Myelogenous Leukemia	FLT3-ITD mutation	Acute Myelogenous Leukemia	quizartinib + GMI-1359 Sensitive: D – Preclinical quizartinib + GMI-1359 Sensitive : D	quizartinib + GMI-1359 Sensitive: D – Preclinical quizartinib + GMI-1359 Sensitive : D