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Association details:
| Biomarker: | DKK1 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | 5-fluorouracil (Thymidylate synthase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
1039 - Andrographis enhances 5-fluorouracil-induced anti-tumor effect in colorectal cancer through inhibition of DKK1
Published date:
03/10/2021
Excerpt:
By analyzing gene expression profiling data from cell lines and CRC patients, we identified that overexpression of DKK1 gene was a critical event for 5FU resistance in CRC.
