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Association details:
| Biomarker: | CXCL13 elevation |
|---|---|
| Cancer: | Clear Cell Renal Cell Carcinoma |
| Drug: | Opdivo (nivolumab) (PD1 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
687P - NIVOREN GETUG-AFU 26 translational study: Baseline peripheral cytokines predict survival in metastatic clear cell renal carcinoma (RCC) treated with nivolumab
Published date:
09/13/2021
Excerpt:
Increased levels of IL-6, BCA and BAFF were significantly negatively associated with survival (IL-6: HR=4.41, 95%CI: 1.26-15.43, p=0.0112; BCA: HR=4.74, 95%CI: 1.35-16.64, p=0.0076, and BAFF: HR=4.39, 95%CI:1.26-15.32, p=0.0114)...Higher baseline plasma levels of IL-6, BCA and BAFF were significantly associated with worse survival outcomes in mRCC pts treated with nivolumab within an exploratory cohort of NIVOREN trial.
Trial ID:
