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Association details:
| Biomarker: | CSF1R overexpression |
|---|---|
| Cancer: | Osteosarcoma |
| Drug: | pimicotinib (ABSK021) (CSF-1R inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
LB329 / 20 - A potent and selective small molecule inhibitor of CSF-1R ABSK021 demonstrates strong efficacy in preclinical models of osteosarcoma
Published date:
03/15/2023
Excerpt:
ABSK021 potently inhibited the proliferation of K7M2, a murine osteosarcoma cell line with high expression of CSF-1R….High prevalence of CSF-1R expression was also found in osteosarcoma patients, suggesting great potential of utilizing ABSK021 as a novel therapy to treat osteosarcoma patients in clinic.
