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GENE:

CRKL (CRK Like Proto-Oncogene, Adaptor Protein)

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CRKL mutation	Non Small Cell Lung Cancer	CRKL mutation	Non Small Cell Lung Cancer	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3	nivolumab + ipilimumab Sensitive: C3 – Early Trials nivolumab + ipilimumab Sensitive : C3
CRKL mutation	Melanoma	CRKL mutation	Melanoma	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3	Immunotherapy Sensitive: C3 – Early Trials Immunotherapy Sensitive : C3
CRKL overexpression + EGFR mutation	Non Small Cell Lung Cancer	CRKL overexpression + EGFR mutation	Non Small Cell Lung Cancer	gefitinib Resistant: D – Preclinical gefitinib Resistant : D	gefitinib Resistant: D – Preclinical gefitinib Resistant : D
CRKL overexpression	Non Small Cell Lung Cancer	CRKL overexpression	Non Small Cell Lung Cancer	gefitinib Resistant: D – Preclinical gefitinib Resistant : D	gefitinib Resistant: D – Preclinical gefitinib Resistant : D
CRKL amplification	Gastric Cancer	CRKL amplification	Gastric Cancer	dasatinib Sensitive: D – Preclinical dasatinib Sensitive : D	dasatinib Sensitive: D – Preclinical dasatinib Sensitive : D