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Association details:
| Biomarker: | Chr t(4;14) |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | PFI-3 (SMARCA2 inhibitor, SMARCA4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
SMARCA2 is a novel interactor of NSD2 and regulates pro-metastatic PTP4A3 through chromatin remodeling in t(4;14) multiple myeloma
Published date:
02/18/2021
Excerpt:
...using the specific BET inhibitor PFI-3...inhibiting t(4;14) myeloma cell viability. In vivo, treatment with PFI-3 reduced the growth of t(4;14) xenograft tumors.
DOI:
10.1158/0008-5472.CAN-20-2946
