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Association details:
| Biomarker: | Chr t(4;14) |
|---|---|
| Cancer: | Multiple Myeloma |
| Drug: | Rydapt (midostaurin) (Multi-tyrosine kinase inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies
Excerpt:
...we tested the inhibitory effects of PKC412 in a more clinically relevant system by performing a dose–response analysis using FGFR3-positive t(4;14)-positive primary MM cell lines, including OPM-1, LP1 and KMS11... PKC412 effectively inhibited the growth of OPM-1 and KMS11 cells (Figure 3a). PKC412 also inhibits LP1 cells with relatively higher cellular IC50...These data suggest that PKC412 effectively inhibits proliferation of FGFR3-positive t(4;14) MM cells...
