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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

338 Venetoclax in Combination with Daratumumab and Dexamethasone Elicits Deep, Durable Responses in Patients with t(11;14) Relapsed/Refractory Multiple Myeloma: Updated Analyses of Minimal Residual Disease Negativity in Phase 1/2 Study

Published date:
11/02/2023
Excerpt:
VenDd achieved 96% ORR, 93% ≥ very good partial response (VGPR), 67% ≥ CR...VenDd treatment showed higher rates of MRD-negativity and sustained MRD-negativity compared to DVd in patients with t(11;14)-positive RRMM, which was associated with longer PFS with VenDd.
Trial ID:
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

4548 Exposure-Response Analysis Supports a Lower Dose of Venetoclax in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma Patients When Combined with Daratumumab and Dexamethasone

Published date:
11/03/2022
Excerpt:
This analysis aimed to select the optimal venetoclax dose in combination with daratumumab and dexamethasone (VenDd) in t(11;14)-positive relapsed/refractory MM patients using data from Study M15-654 (NCI: NCT03314181) which evaluated VenDd versus bortezomib in combination with daratumumab and dexamethasone (DVd)...compared to the control arm, venetoclax resulted in higher response rates (very good partial response or better [≥VGPR] and complete response or better [≥CR]) and longer PFS (PFS data not mature at time of analysis).
DOI:
https://doi.org/10.1182/blood-2022-166429
Trial ID:
Evidence Level:
Sensitive: C3 – Early Trials
Title:

Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14)

Published date:
08/13/2021
Excerpt:
The 18-month progression-free survival rate was 90.5% (95% CI, 67.0 to 97.5) with VenDd and 66.7% (95% CI, 42.5 to 82.5) with VenDVd….VenDd and VenDVd produced a high rate of deep and durable responses in patients with RRMM. These results support continued evaluation of venetoclax with daratumumab regimens to treat RRMM, particularly in those with t(11;14).
Secondary therapy:
bortezomib
DOI:
10.1200/JCO.21.00443
Trial ID: