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BIOMARKER:
Chr t(11;14)
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Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax
Sensitive: A2 - Guideline
venetoclax
Sensitive
:
A2
venetoclax
Sensitive: A2 - Guideline
venetoclax
Sensitive
:
A2
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
Sensitive: A2 - Guideline
Sensitive
:
A2
Sensitive: A2 - Guideline
Sensitive
:
A2
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + bortezomib
Sensitive: B - Late Trials
venetoclax + bortezomib
Sensitive
:
B
venetoclax + bortezomib
Sensitive: B - Late Trials
venetoclax + bortezomib
Sensitive
:
B
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
Resistant: B - Late Trials
Resistant
:
B
Resistant: B - Late Trials
Resistant
:
B
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
Resistant: B - Late Trials
Resistant
:
B
Resistant: B - Late Trials
Resistant
:
B
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax
Sensitive: C2 – Inclusion Criteria
venetoclax
Sensitive
:
C2
venetoclax
Sensitive: C2 – Inclusion Criteria
venetoclax
Sensitive
:
C2
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + atezolizumab + cobimetinib
Sensitive: C2 – Inclusion Criteria
venetoclax + atezolizumab + cobimetinib
Sensitive
:
C2
venetoclax + atezolizumab + cobimetinib
Sensitive: C2 – Inclusion Criteria
venetoclax + atezolizumab + cobimetinib
Sensitive
:
C2
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
Resistant: C3 – Early Trials
Resistant
:
C3
Resistant: C3 – Early Trials
Resistant
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
bortezomib
Sensitive: C3 – Early Trials
bortezomib
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
BRAF inhibitor + MEK inhibitor
Sensitive: C3 – Early Trials
BRAF inhibitor + MEK inhibitor
Sensitive
:
C3
BRAF inhibitor + MEK inhibitor
Sensitive: C3 – Early Trials
BRAF inhibitor + MEK inhibitor
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
BRAF inhibitor
Sensitive: C3 – Early Trials
BRAF inhibitor
Sensitive
:
C3
BRAF inhibitor
Sensitive: C3 – Early Trials
BRAF inhibitor
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + cobimetinib
Sensitive: C3 – Early Trials
venetoclax + cobimetinib
Sensitive
:
C3
venetoclax + cobimetinib
Sensitive: C3 – Early Trials
venetoclax + cobimetinib
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + daratumumab
Sensitive: C3 – Early Trials
venetoclax + daratumumab
Sensitive
:
C3
venetoclax + daratumumab
Sensitive: C3 – Early Trials
venetoclax + daratumumab
Sensitive
:
C3
Chr t(11;14)
Mantle Cell Lymphoma
Chr t(11;14)
Mantle Cell Lymphoma
INCB50465
Sensitive: C3 – Early Trials
INCB50465
Sensitive
:
C3
INCB50465
Sensitive: C3 – Early Trials
INCB50465
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
pomalidomide
Sensitive: C3 – Early Trials
pomalidomide
Sensitive
:
C3
pomalidomide
Sensitive: C3 – Early Trials
pomalidomide
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
ARRY-520
Sensitive: C3 – Early Trials
ARRY-520
Sensitive
:
C3
ARRY-520
Sensitive: C3 – Early Trials
ARRY-520
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
venetoclax + selinexor
Sensitive: C3 – Early Trials
venetoclax + selinexor
Sensitive
:
C3
venetoclax + selinexor
Sensitive: C3 – Early Trials
venetoclax + selinexor
Sensitive
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
lenalidomide
Resistant: C3 – Early Trials
lenalidomide
Resistant
:
C3
lenalidomide
Resistant: C3 – Early Trials
lenalidomide
Resistant
:
C3
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
BGB-11417
Sensitive: C3 – Early Trials
BGB-11417
Sensitive
:
C3
BGB-11417
Sensitive: C3 – Early Trials
BGB-11417
Sensitive
:
C3
Chr t(11;14)
Leukemia
Chr t(11;14)
Leukemia
DOT1L inhibitor + venetoclax
Sensitive: D – Preclinical
DOT1L inhibitor + venetoclax
Sensitive
:
D
DOT1L inhibitor + venetoclax
Sensitive: D – Preclinical
DOT1L inhibitor + venetoclax
Sensitive
:
D
Chr t(11;14)
Multiple Myeloma
Chr t(11;14)
Multiple Myeloma
APG-2575
Sensitive: D – Preclinical
APG-2575
Sensitive
:
D
APG-2575
Sensitive: D – Preclinical
APG-2575
Sensitive
:
D
^
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