Recommendations: Patients who receive second-line therapy: VenVd is a suitable option for patients with t(11;14) who have failed lenalidomide and are sensitive to PIs [I, A], if available….Patients at third and subsequent lines of treatment: Patients with t(11;14), who are refractory to lenalidomide and are PI-sensitive may be treated with VenVd [I, A], if available.