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    Association details:
    Biomarker:CFLAR expression
    Cancer:Prostate Cancer
    Drug:bicalutamide (Androgen receptor inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Clin Cancer Res
    Title:

    Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy

    Excerpt:
    Conversely, the elevated expression of c-FLIP detected in the CRPC cell line VCaP underpinned their insensitivity to bicalutamide and SAHA in vitro.
    DOI:
    10.1158/1078-0432.CCR-11-3277