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BIOMARKER:

CDK12 mutation

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Other names: CDK12, Cyclin Dependent Kinase 12, Cdc2-Related Kinase, Arginine/Serine-Rich, Cell Division Cycle 2-Related Protein Kinase 7, Cell Division Protein Kinase 12, CDC2-Related Protein Kinase 7, Cyclin-Dependent Kinase 12, CRKRS, CRK7, CDC2 Related Protein Kinase 7, HCDK12, CrkRS, CRKR
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Entrez ID:
Related biomarkers:
CDK12 mutation
Prostate Cancer
olaparib
Sensitive
:
A2
CDK12 mutation
Ovarian Cancer
olaparib
Sensitive
:
B
CDK12 mutation
Prostate Cancer
nivolumab
Sensitive
:
C2
CDK12 mutation
HER2 Negative Breast Cancer
durvalumab
Sensitive
:
C2
CDK12 mutation
Prostate Cancer
pembrolizumab
Sensitive
:
C3
CDK12 mutation
Prostate Cancer
abiraterone acetate
Resistant
:
C3
CDK12 mutation
Prostate Cancer
enzalutamide capsule
Resistant
:
C3
CDK12 mutation
Prostate Cancer
rucaparib
Resistant
:
C3
CDK12 mutation
Breast Cancer
olaparib
Sensitive
:
C3
CDK12 mutation
Prostate Cancer
GnRH stimulant
Resistant
:
C3
CDK12 mutation
Prostate Cancer
Immunotherapy
Resistant
:
C3
CDK12 mutation
Prostate Cancer
enzalutamide capsule + abiraterone acetate
Resistant
:
C3
CDK12 mutation
Ovarian Cancer
rucaparib
Sensitive
:
C3
CDK12 mutation
Non Small Cell Lung Cancer
olaparib
Sensitive
:
C4
CDK12 mutation
Prostate Cancer
nivolumab + ipilimumab
Sensitive
:
C4