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Association details:
| Biomarker: | CDH1 deletion |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | mocetinostat (MGCD0103) (HDAC inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors
Published date:
12/30/2021
Excerpt:
CDH1-/- breast and gastric cells were more sensitive to the pan-HDAC inhibitors entinostat, pracinostat, mocetinostat and vorinostat than wild-type cells, with an elevated growth inhibition that was, in part, attributable to increased apoptosis....Finally, entinostat enhanced Cdh1 expression in heterozygous Cdh1+/- murine organoids. In conclusion, entinostat is a promising drug for the chemoprevention and/or treatment of HDGC and may also be beneficial for the treatment of sporadic CDH1-deficient cancers.
DOI:
10.3390/cancers14010175
