A 33-year-old male...diagnosis of primary CD20 negative DLBCL, which is a high-grade lymphoma, we started him on infusion chemotherapy regimen i.e. EPOCH (Etoposide, Prednisolone, Doxorubicin, vincristine along with bolus of cyclophosphamide). His follow-up interim scan done after four cycles of EPOCH did not show any change in the disease status (treatment failure)...Our patient did not respond to EPOCH chemotherapy regimen.