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Association details:
| Biomarker: | CD123 positive |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | VIP943 (CD123-targeted antibody-drug conjugate, KIF11 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies
Published date:
11/20/2020
Excerpt:
...we describe BAY-943 (IL3RA-ADC), a novel IL3RA-targeting ADC consisting of a humanized anti-IL3RA antibody conjugated to a potent proprietary kinesin spindle protein inhibitor (KSPi)...In vivo, IL3RA-ADC improved survival and reduced tumor burden in IL3RA-positive human AML cell line-derived (MOLM-13 and MV-4-11) as well as in patient-derived xenograft (PDX) models (AM7577 and AML11655) in mice...Overall, the preclinical results support the further development of BAY-943 as an innovative approach for the treatment of IL3RA-positive hematologic malignancies.
DOI:
10.3390/cancers12113464
