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Association details:
| Biomarker: | CBL mutation |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug: | SU11274 (c-MET inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL
Excerpt:
We investigated if MET is a target of CBL and if enhanced in CBL-altered NSCLC. We showed that CBL wildtype cells have lower MET expression than CBL mutant cells. Ubiquitination of MET was also decreased in CBL mutant cells compared to wildtype cells. Mutant cells were also more sensitive to MET inhibitor SU11274 than wild-type cells.
DOI:
10.1038/s41598-017-09078-4
