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Association details:
| Biomarker: | CBFA2T3 - GLIS2 fusion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | GANT61 (Hedgehog cell-signalling pathway inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene
Published date:
01/21/2017
Excerpt:
...we investigated the in vitro effects of GANT61 on AML cell lines and primary cells from AML patients harboring the CBFA2T3-GLIS2 fusion gene...Our results showed that AML cell lines with CBFA2T3-GLIS2 fusion gene have a higher sensitivity to GANT61 than other AML cell lines without this genetic aberration...
DOI:
10.1186/s13045-017-0396-0
