^
Association details:
| Biomarker: | CASP8 overexpression |
|---|---|
| Cancer: | Ewing Sarcoma |
| Drug: | conatumumab (AMG 655) (TRAIL R2 agonist) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma
Excerpt:
In vivo, conatumumab is active against an EWS cell line and a patient-derived xenograft with higher caspase-8 expression…
DOI:
10.1038/bjc.2015.298
