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Association details:
| Biomarker: | CA6 expression |
|---|---|
| Cancer: | Cervical Cancer |
| Drug: | SAR566658 (Microtubule inhibitor, CA6-targeted antibody-drug conjugate) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
An Antibody–Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities
Excerpt:
SAR566658 showed in vivo antitumor efficacy against CA6-positive human pancreas, cervix, bladder, and ovary tumor xenografts and against three breast patient-derived xenografts. Tumor regression was observed in all tumor models with minimal effective dose correlating with CA6 expression. SAR566658 displayed better efficacy than standard-of-care nontargeted tubulin binders. These data support the development of SAR566658 in patients with CA6-expressing tumors.
DOI:
https://doi.org/10.1158/1535-7163.MCT-19-0826
