^
Association details:
Biomarker:BTK C481S
Cancer:Mantle Cell Lymphoma
Drug:Imbruvica (ibrutinib) (BTK inhibitor)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: D – Preclinical
Title:

The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphoma

Published date:
07/30/2021
Excerpt:
In further support, SRX3262 treatment led to an increase in apoptotic cell death in either JeKo-1 BTK-WT or Ibrutinib-resistant cells JeKo-1 BTK-C481S and Mino BTK-C481S (Figures 4E and 4F). In contrast, Ibrutinib failed to induce apoptosis at the same concentrations as SRX3262, up to 5 μM.
DOI:
10.1016/j.isci.2021.102931