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    Association details:
    Biomarker:BRD4 overexpression
    Cancer:Retinoblastoma
    Drug:JQ-1 (BET inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Exp Eye Res
    Title:

    JQ1, a selective inhibitor of BRD4, suppresses retinoblastoma cell growth by inducing cell cycle arrest and apoptosis

    Published date:
    10/17/2020
    Excerpt:
    ...BRD4 was overexpressed in retinoblastoma, and JQ1 effectively inhibited RB cell proliferation and colony formation by inducing cell cycle arrest and promoting apoptosis.
    DOI:
    https://doi.org/10.1016/j.exer.2020.108304