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Association details:
Biomarker:BRD4 overexpression
Cancer:Retinoblastoma
Drug:JQ-1 (BET inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

JQ1, a selective inhibitor of BRD4, suppresses retinoblastoma cell growth by inducing cell cycle arrest and apoptosis

Published date:
10/17/2020
Excerpt:
...BRD4 was overexpressed in retinoblastoma, and JQ1 effectively inhibited RB cell proliferation and colony formation by inducing cell cycle arrest and promoting apoptosis.
DOI:
https://doi.org/10.1016/j.exer.2020.108304