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BIOMARKER:
BRCA1 deletion
i
Other names:
BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
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Entrez ID:
672
Related biomarkers:
Expression
Mutation
Fusion
Others
‹
HRD + BRCA1 mutation (7)
BRCA1 mutation + HR positive (3)
BRCA1 mutation + TMB-H (3)
BRCA1 2080delA + CCNE1 overexpression (2)
BRCA1 mutation + HER-2 negative (2)
HR negative + BRCA1 mutation (2)
HR positive + BRCA1 mutation (2)
BAP1 negative + BRCA1 mutation (1)
BRCA1 hypermethylation (1)
BRCA1 mutation + AKR1C3 overexpression (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA1 mutation + PD-L1 expression (1)
BRCA1 mutation + RAD51B deletion (1)
BRCA1 mutation + RB1 deletion (1)
BRCA1 promoter methylation (1)
EGFR mutation + BRCA1 overexpression (1)
EGFR mutation + BRCA1 underexpression (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
PTEN deletion + BRCA1 mutation (1)
ER positive + BRCA1 mutation (0)
HRD + BRCA1 mutation (7)
BRCA1 mutation + HR positive (3)
BRCA1 mutation + TMB-H (3)
BRCA1 2080delA + CCNE1 overexpression (2)
BRCA1 mutation + HER-2 negative (2)
HR negative + BRCA1 mutation (2)
HR positive + BRCA1 mutation (2)
BAP1 negative + BRCA1 mutation (1)
BRCA1 hypermethylation (1)
BRCA1 mutation + AKR1C3 overexpression (1)
BRCA1 mutation + BRCA2 mutation + TMB-H (1)
BRCA1 mutation + HER-2 negative + ER positive + PGR positive (1)
BRCA1 mutation + PD-L1 expression (1)
BRCA1 mutation + RAD51B deletion (1)
BRCA1 mutation + RB1 deletion (1)
BRCA1 promoter methylation (1)
EGFR mutation + BRCA1 overexpression (1)
EGFR mutation + BRCA1 underexpression (1)
HR positive + BRCA1 mutation + PALB2 mutation (1)
PTEN deletion + BRCA1 mutation (1)
ER positive + BRCA1 mutation (0)
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Associations
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Trials
VERI cancer hierarchy
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BRCA1 deletion
Prostate Cancer
BRCA1 deletion
Prostate Cancer
rucaparib
Sensitive: C3 – Early Trials
rucaparib
Sensitive
:
C3
rucaparib
Sensitive: C3 – Early Trials
rucaparib
Sensitive
:
C3
BRCA1 deletion
Ovarian Cancer
BRCA1 deletion
Ovarian Cancer
rucaparib
Sensitive: C3 – Early Trials
rucaparib
Sensitive
:
C3
rucaparib
Sensitive: C3 – Early Trials
rucaparib
Sensitive
:
C3
BRCA1 deletion
Ovarian Cancer
BRCA1 deletion
Ovarian Cancer
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
BRCA1 deletion
Ovarian Serous Adenocarcinoma
BRCA1 deletion
Ovarian Serous Adenocarcinoma
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
bevacizumab
Sensitive: C3 – Early Trials
bevacizumab
Sensitive
:
C3
BRCA1 deletion
Triple Negative Breast Cancer
BRCA1 deletion
Triple Negative Breast Cancer
PARP inhibitor
Sensitive: D – Preclinical
PARP inhibitor
Sensitive
:
D
PARP inhibitor
Sensitive: D – Preclinical
PARP inhibitor
Sensitive
:
D
BRCA1 deletion
Triple Negative Breast Cancer
BRCA1 deletion
Triple Negative Breast Cancer
olaparib
Sensitive: D – Preclinical
olaparib
Sensitive
:
D
olaparib
Sensitive: D – Preclinical
olaparib
Sensitive
:
D
BRCA1 deletion
Solid Tumor
BRCA1 deletion
Solid Tumor
PLX038
Sensitive: D – Preclinical
PLX038
Sensitive
:
D
PLX038
Sensitive: D – Preclinical
PLX038
Sensitive
:
D
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