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Association details:
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
Source:
Title:

Ovarian Cancer With Breast Metastasis and Two Pathogenic Variants of BRCA1 Gene

Published date:
10/11/2021
Excerpt:
...42-year-old Chinese woman with high-grade serous ovarian carcinoma…ovarian tumor showed two BRCA1 pathogenic variants. Germline pathogenic variant of c.2110_2111DelAA and a somatic variant of c.4071_4096+14del40…additional oncogenic mutations; TP53 c.1025G>C p.R342P and NOTCH2 c.3930G> p.Q1310H...First trial PARP inhibitor with mTORC1/2 inhibitor or oral AKT inhibitors. According to RECIST1.1 (Response Evaluation Criteria in Solid Tumors) criteria, the patient showed disease progression.
DOI:
doi:10.7759/cureus.18691