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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

2608 / 21 - Pre-clinical evaluation of small molecule CHK2 inhibitor, ART-122 combined with olaparib in BRCA wild type tumors

Published date:
03/09/2022
Excerpt:
The combination of ART-122 and Olaparib demonstrated a synergistic effect in BRCA wild-type ovarian and breast tumor cell lines. In the mouse xenograft model, the CHK2 inhibitor ART-122 sensitized BRCA1/2 wild-type tumor cells MDA-MB-231 to olaparib treatment.