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Association details:
| Biomarker: | BRAF V600G |
|---|---|
| Cancer: | Melanoma |
| Drug: | Tafinlar (dabrafenib) (BRAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
RAF Inhibitor Dabrafenib (GSK2118436) is Active in Melanoma Brain Metastases, Multiple BRAF Genotypes and Diverse Cancers
Excerpt:
Responses were observed in patients with non-V600E BRAF mutations, including V600K and V600G….Dabrafenib is a highly active inhibitor of V600-mutant BRAF with a high response rate in V600E melanoma…
DOI:
10.1016/S0140-6736(12)60398-5
Trial ID:
