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Association details:
Biomarker:
BRAF V600E
Cancer:
Prolymphocytic Leukemia
Drug:
dasatinib
(
c-KIT inhibitor
,
Bcr-abl tyrosine kinase inhibitor
,
Src kinase inhibitor
,
EphA2 receptor antagonist
,
PDGFR β antagonist
)
Direction:
Resistant
Evidence:
Evidence Level:
Resistant: C4 – Case Studies
Source:
Br J Haematol
Title:
First reported case of BRAF V600E mutation in T-cell prolymphocytic leukaemia
Published date:
07/25/2020
Excerpt:
Our patient, having progressed through standard of care treatments, was trialled on novel treatments including dasatinib, venetoclax and vemurafenib.
DOI:
10.1111/bjh.16992
Test:
FoundationOne® Heme CDx
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