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    Association details:
    Biomarker:BRAF V600E
    Cancer:Esophageal Adenocarcinoma
    Drug:Mekinist (trametinib) (MEK inhibitor) +
    Tafinlar (dabrafenib) (BRAF inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    New
    Source:
    NCCN
    Published date:
    02/28/2023
    Excerpt:
    Esophageal and Esophagogastric Junction Cancers...ADENOCARCINOMA….Useful in Certain Circumstances:…Dabrafenib and trametinib for BRAF V600E mutated tumors
    Evidence Level:
    Sensitive: C1 - Off-label
      (Approved for Non Small Cell Lung Cancer)
    Excerpt:
    TAFINLAR is indicated, in combination with trametinib, for...the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation as detected by an FDA-approved test.