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Association details:
| Biomarker: | BRAF V600E + RNF43 mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug Class: | BRAF inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BRAF V600E and RNF43 Co-mutations Predict Patient Outcomes With Targeted Therapies in Real-World Cases of Colorectal Cancer
Published date:
02/13/2023
Excerpt:
This study aimed to independently and rapidly validate BRAFV600E/RNF43 co-mutations as predictive biomarkers of benefit to anti-EGFR/BRAF therapy....Real-world cases of BRAFV600E-mutated mCRC, with patients receiving anti-BRAF/EGFR therapy (n = 49), were included. Patients who were MSS, with RNF43 mutations, had favorable progression-free survival (hazard ratio [HR] 0.29; 95% CI [CI], 0.13-0.65) and overall survival (HR 0.32, 95% CI, 0.12-0.84)...
DOI:
10.1093/oncolo/oyac265
