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    Association details:
    Biomarker:BRAF K601E
    Cancer:Melanoma
    Drug:U0126 (MEK1 inhibitor, MEK2 inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Oncogene
    Title:

    CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

    Excerpt:
    D594G (WM3629) and the G469E (WM3670) melanoma cell lines are nearly completely resistant to the growth inhibitory effects of the MEK inhibitor U0126, In contrast, the melanoma cell lines harboring either the BRAF V600E or K601E mutation were markedly growth inhibited following U0126 treatment.
    DOI:
    10.1038/onc.2008.362