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Association details:
Evidence:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

DPX-Survivac and Checkpoint Inhibitor in DLBCL

Excerpt:
...To document the objective response rate using modified Cheson criteria to treatment with DPX-Survivac and low dose cyclophosphamide administered together with Pembrolizumab in participants with recurrent, survivin-expressing B cell lymphomas...
Trial ID:
Evidence Level:
Sensitive: C2 – Inclusion Criteria
Title:

DPX-Survivac and Checkpoint Inhibitor in DLBCL

Excerpt:
...Subjects must have evidence of survivin expression in pre-treatment tumour sample (> 10% of tumour cells stained)....
Less C2 evidence
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

2114 Clinical Effectiveness of Combination Immunotherapy DPX-Survivac, Low Dose Cyclophosphamide, and Pembrolizumab in Recurrent/Refractory DLBCL: The Spirel Study

Published date:
11/04/2020
Excerpt:
Analyses of peripheral blood T cell responses to survivin by ELISpot assay shows that 7/7 subjects who achieved an objective response have survivin-specific T cell response. One subject with PD also showed a survivin-specific T cell response, supporting the mechanism of action and the role of DPX-Survivac in anti-tumor activity.
Secondary therapy:
cyclophosphamide