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Association details:
Evidence:
Evidence Level:
Sensitive: C3 – Early Trials
New
Title:

Dasatinib in Imatinib-Resistant Philadelphia Chromosome–Positive Leukemias

Excerpt:
A complete hematologic response was achieved in 37 of 40 patients with chronic-phase CML, and major hematologic responses were seen in 31 of 44 patients with accelerated-phase CML, CML with blast crisis, or Ph-positive ALL….Dasatinib induces hematologic and cytogenetic responses in patients with CML or Ph-positive ALL who cannot tolerate or are resistant to imatinib...Supplemental Table 3 - Summary of Dasatinib Treatment Responses, Prior Imatinib Response and Bcr/Abl Genotype in Chronic Phase Patients.
DOI:
10.1056/NEJMoa055229
Trial ID: