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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition

Published date:
11/04/2021
Excerpt:
SBI-756, a small molecule inhibitor of eIF4F assembly, sensitizes human Ph+ and Ph-like B-ALL cells to dasatinib cytotoxicity without affecting survival of T lymphocytes or natural killer cells. These findings support the further evaluation of eIF4F-targeted molecules in combination therapies with TKIs in B-ALL and other blood cancers.
DOI:
10.1038/s41598-021-00950-y