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Association details:
| Biomarker: | BAP1 mutation |
|---|---|
| Cancer: | Solid Tumor |
| Drug Class: | BET inhibitor |
| Direction: | Sensitive |
Evidence:
Source:
Title:
BAP1 loss augments sensitivity to BET inhibitors in cancer cells
Published date:
11/04/2021
Excerpt:
The association of BAP1 loss with sensitivity to BET inhibitors is observed in multiple BAP1-deficient cancer cell lines generated by gene editing or derived from patient tumors as well as immunodeficient xenograft and immunocompetent allograft murine models....Our study reveals new approaches to specifically suppress BAP1-deficient cancers, including CM, UM, and ccRCC.
DOI:
10.1038/s41401-021-00783-5
