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BIOMARKER:
BAP1 deletion
i
Other names:
BAP1, BRCA1 Associated Protein 1, BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase), Ubiquitin Carboxyl-Terminal Hydrolase BAP1, Cerebral Protein 6, Ubiquitin Carboxy-Terminal Hydrolase, BRCA1-Associated Protein 1, Cerebral Protein-13, HUCEP-13, KIAA0272, Hucep-6, UCHL2
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Entrez ID:
8314
Related biomarkers:
Expression
Mutation
CNA
Others
‹
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
BAP1 581-17_585del22 + RAD21 amplification (1)
BAP1 R300Gfs*6 + PD-L1 expression (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BAP1 mutation + FGFR2 fusion (1)
BAP1 mutation + IDH2 R172W + CDKN2A deletion + CDKN2B deletion (1)
BAP1 negative + BRCA1 mutation (1)
CAMK2D overexpression + BAP1 deletion (0)
TMB-L + BAP1 V99M + NF2 R34 + Chr del(14q) + Chr del(19q) (2)
BAP1 581-17_585del22 + RAD21 amplification (1)
BAP1 R300Gfs*6 + PD-L1 expression (1)
BAP1 deletion + TMB-L + PD-L1 expression (1)
BAP1 mutation + FGFR2 fusion (1)
BAP1 mutation + IDH2 R172W + CDKN2A deletion + CDKN2B deletion (1)
BAP1 negative + BRCA1 mutation (1)
CAMK2D overexpression + BAP1 deletion (0)
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Associations
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VERI cancer hierarchy
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BAP1 deletion
Malignant Pleural Mesothelioma
BAP1 deletion
Malignant Pleural Mesothelioma
pemetrexed
Sensitive: C3 – Early Trials
pemetrexed
Sensitive
:
C3
pemetrexed
Sensitive: C3 – Early Trials
pemetrexed
Sensitive
:
C3
BAP1 deletion
Malignant Pleural Mesothelioma
BAP1 deletion
Malignant Pleural Mesothelioma
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
nivolumab + ipilimumab
Sensitive: C3 – Early Trials
nivolumab + ipilimumab
Sensitive
:
C3
BAP1 deletion
Renal Cell Carcinoma
BAP1 deletion
Renal Cell Carcinoma
olaparib
Sensitive: D – Preclinical
olaparib
Sensitive
:
D
olaparib
Sensitive: D – Preclinical
olaparib
Sensitive
:
D
BAP1 deletion
Mesothelioma
BAP1 deletion
Mesothelioma
FGFR inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
FGFR inhibitor + EZH2 inhibitor
Sensitive
:
D
FGFR inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
FGFR inhibitor + EZH2 inhibitor
Sensitive
:
D
BAP1 deletion
Uveal Melanoma
BAP1 deletion
Uveal Melanoma
FGFR inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
FGFR inhibitor + EZH2 inhibitor
Sensitive
:
D
FGFR inhibitor + EZH2 inhibitor
Sensitive: D – Preclinical
FGFR inhibitor + EZH2 inhibitor
Sensitive
:
D
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