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Association details:
Biomarker:BACH2 overexpression
Cancer:Diffuse Large B Cell Lymphoma
Regimen:R-CHOP (cyclophosphamide + doxorubicin hydrochloride + prednisone + Rituxan (rituximab) + vincristine)
Direction:Resistant
Evidence:
Evidence Level:
Resistant: C3 – Early Trials
New
Source:
Title:

Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma

Excerpt:
All patients were treated with rituximab-containing chemotherapy...In cases with high BACH2-expression, 3-year OS rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256). The 3-year PFS was also shorter than that with low expression, although it was not significant (62.5% vs 80.3%, P = 0.0681).
DOI:
10.1111/cas.12361