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DRUG CLASS:

B7-H4-targeted antibody-drug conjugate

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B7-H4-targeted antibody-drug conjugate

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PF-08046048 (4)

PF-08046048 (4)

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No biomarker	Triple Negative Breast Cancer	No biomarker	Triple Negative Breast Cancer	XMT-1660 Sensitive: B - Late Trials XMT-1660 Sensitive : B	XMT-1660 Sensitive: B - Late Trials XMT-1660 Sensitive : B
ER positive	HER2 Negative Breast Cancer	ER positive	HER2 Negative Breast Cancer	XMT-1660 Sensitive: D – Preclinical XMT-1660 Sensitive : D	XMT-1660 Sensitive: D – Preclinical XMT-1660 Sensitive : D
VTCN1 underexpression	Breast Cancer	VTCN1 underexpression	Breast Cancer	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D
VTCN1 underexpression	Ovarian Cancer	VTCN1 underexpression	Ovarian Cancer	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D
VTCN1 overexpression	Solid Tumor	VTCN1 overexpression	Solid Tumor	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D
VTCN1 underexpression	Solid Tumor	VTCN1 underexpression	Solid Tumor	AZD8205 + AZD5305 Sensitive: D – Preclinical AZD8205 + AZD5305 Sensitive : D	AZD8205 + AZD5305 Sensitive: D – Preclinical AZD8205 + AZD5305 Sensitive : D
VTCN1 underexpression	Cholangiocarcinoma	VTCN1 underexpression	Cholangiocarcinoma	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D
VTCN1 underexpression	Ovarian Cancer	VTCN1 underexpression	Ovarian Cancer	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D
VTCN1 underexpression	Triple Negative Breast Cancer	VTCN1 underexpression	Triple Negative Breast Cancer	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D
VTCN1 expression	Solid Tumor	VTCN1 expression	Solid Tumor	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D	PF-08046048 Sensitive: D – Preclinical PF-08046048 Sensitive : D
VTCN1 expression + DDR	Solid Tumor	VTCN1 expression + DDR	Solid Tumor	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D	AZD8205 Sensitive: D – Preclinical AZD8205 Sensitive : D
VTCN1 expression	Breast Cancer	VTCN1 expression	Breast Cancer	XMT-1660 Sensitive: D – Preclinical XMT-1660 Sensitive : D	XMT-1660 Sensitive: D – Preclinical XMT-1660 Sensitive : D