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Association details:
| Biomarker: | ATM mutation |
|---|---|
| Cancer: | Hematological Malignancies |
| Drug: | LP-284 (Alkylating agent, DNA repair enzyme inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Targeting Homologous Recombination Deficiencies in B‑Cell Non‑Hodgkin Lymphomas With the Novel Anti‑Tumor Small Molecule LP‑284
Published date:
09/01/2023
Excerpt:
LP-284 is a small acylfulvene molecule with demonstrated antitumor activity in preclinical hematologic cancer cell models and cells deficient in DDR, such as compromised ataxia telangiectasia mutated (ATM).
